The Cancer Pharmacokinetics and Pharmacodynamics Core (CPPC) at H. Lee Moffitt Cancer Center and Research Institute aims to provide a broad spectrum of high quality and cost-effective services including in vitro ADME and PK, physicochemical profiling, bioanalytical method development, analysis of drugs and metabolites in bodily fluids and tissues, as well as PD endpoints quantification for preclinical and early phase clinical trials.

Position Highlights:

• The Research Specialist I (RSI) will be responsible for independently performing specialized assays on pre-clinical and clinical samples for drug quantitation and molecular endpoints.
• The RSI position will support a full line of services offered by the core along with maintaining routine laboratory functions in a team environment.

The Ideal Candidate:

• The skillsets to perform primary laboratory duties, such as maintaining cell line cultures, biological sample processing (specifically peripheral blood mononuclear cell separation), experience in working with biological fluids (blood, serum, urine, etc.) and working with Laboratory Information Management Systems (LIMS).
• Pipetting skills: including mastery of plate-based assays using multi-channel pipettes.
• Working knowledge of automated liquid handlers, luminescent/fluorescence technologies, HPLC instrumentation, and Mass Spectrometry.
• Research experience in in vitro testing of chemotherapeutics including viability, cytotoxicity, and apoptosis assays are preferred.
• Experience in cellular extractions and multiplex immunoassays such as Luminex and Electrochemiluminescence (ELISA) assays is desirable.
• Ability to work flexible hours to meet the needs of the customers.
• Excellent written and verbal communication skills.

Responsibilities:

• Handling and processing cell dissociation and enrichment (e.g., ficoll and antibody labeled magnetic bead enrichment) on human liquid and solid tissue specimens.
• Perform drug response assays and immuno/chemical enzyme linked immunosorbent assays (ELISA).
• Maintain and process cell line cultures and peripheral blood monocular cells in a sterile environment.
• Apply scientific techniques to processing procedures for biological sample preparation (protein-protein precipitation, liquid-liquid extraction and solid phase extraction) for HPLC methodologies.
• Must be able to perform with minimal supervision, strong ability to multi-task, and adhere to project timelines.

Credentials and Qualifications:

• High School Diploma/GED required, Associate's or Bachelor's Degree in Biology, Chemistry, Biochemistry, Immunology or related scientific field preferred.
  • A minimum of two years in a science related field with High School Diploma. 
  • One year of laboratory experience with AA/AS degree.
  • No experience required with BS/BA degree. 
• Core specific licensure and/or certifications are preferred.
• Proficient Microsoft Office skills (Word, Excel, PowerPoint, etc.)